Tag: IVF

Are We One Step Closer To Genetically-Modified Babies?

DNA

Genetically-modified human embryos could be made in a British lab within months.

The fertility regulator will meet tomorrow to decide whether scientists should be allowed to manipulate the genes of embryos donated by IVF patients.




If the researchers at the Francis Crick Institute in London get the go-ahead they will be the first in Britain to alter the DNA of human embryos and only the second in the world.

However, the development, which is made possible by a new, highly precise way of manipulating genes, will raise concerns that Britain is on a slippery slope towards designer babies.

Used differently, the Crispr DNA editing technique could lead to the creation of ‘perfect’ children made to order by hair or eye color.

IVF

Researcher Kathy Niakan has asked the Human Fertilisation & Embryology Authority for permission to study how an embryo’s genes affect whether it will survive the first week of life – a key time in the development of any future baby.

Currently, fewer than one in two eggs live for a week after fertilisation – and just one in eight lead to a pregnancy that lasts at least three months.

Learning more about this ‘critical’ first week of human life could allow more women to have babies by sparing them trauma of miscarriages.

Ivf

It should also improve IVF success rates, cutting the financial and emotional costs of repeated treatments.

New contraceptives could also be in the pipeline.

Dr Niakan said: “The reason this is so important is that repeated miscarriages are unfortunately extremely common but they are not very well understood. One of the main aims is to understand these very early stages of human development.”

“We believe this research could lead to improvements in fertility treatment, provide a really fundamental insight into some of the causes of miscarriage and a much deeper understanding of the earliest stages of human life.”

DNA

By stopping genes from working one by one, she hopes to find out which are key.

If the project is approved by the HFEA and a separate ethics committee, work could start in March and the first GM embryos made by the summer.

Please like, share and tweet this article.

Pass it on: Popular Science

Inside The High-Tech Plot To Save The Northern White Rhino From Extinction

Immediately after the world’s last male northern white rhino died on March 19th, a team of vets got to work. Within 30 minutes, they had collected tissue from the ears, gums, spleen, windpipes, and testicles of the 45-year-old rhino, named Sudan.

The precious genetic material was put in a solution and then frozen at the Ol Pejeta Conservancy in Kenya, where Sudan spent the last nine years of his life.

Those cells could one day bring the northern white rhino back from the brink of extinction.

Dozens of scientists across the globe — from the US to Europe to Africa — are working together tirelessly to figure out ways to breed rhino embryos in the lab.

The effort resembles in some ways the popular de-extinction projects that are attempting to resurrect the woolly mammoth or the passenger pigeon; all want to reverse extinction and in some cases, fix the damage humans have done.




The odds of success for the rhino are much higher: Unlike species that have been extinct for decades (or thousands of years!), northern white rhino DNA and sperm are preserved safely in different labs around the world.

If it works, the project could bring back herds of northern whites that used to roam the grasslands of east and central Africa, where they were poached for their horns.

They are at the brink of extinction only due to human activity,” says Jan Stejskal, director of communication and international projects at the Dvůr Králové Zoo in the Czech Republic, where Sudan lived until 2009.

If we have the techniques or methods to assist them to survive, I think it is our responsibility to utilize them.”

De-extinction has been a sci-fi trope for decades — but now the science may have finally caught up to our imagination.

Today, projects like the Woolly Mammoth Revival led by Harvard’s George Church are trying to use biotechnology to resurrect the extinct species and repopulate the tundras and forests of Siberia and North America.

It works like this: bits of mammoth DNA are edited into the genetic code of its living cousin, the Asian elephant.

A hybrid embryo would then be grown in an Asian elephant surrogate mother — or an artificial womb, Church says — to give birth to a new mammoth-elephant animal.

Despite claims that the hybrid embryo could be created as soon as next year, the project is far from resurrecting herds of mammoths.

It has, however, kicked off a heated debate about whether de-extinction technology should even be used. Many argue that the money spent to bring back long-gone species should be devoted to preserve the ones that are still around.

Others criticize the ethics of resurrecting species whose habitats might be gone and putting surrogate mothers at risk.

Breeding a herd of northern white rhinos is estimated to cost as much as $9 million, according to the Dvůr Králové Zoo, with much of the money coming from donations and zoo revenue.

The San Diego Zoo, which is also involved in the project, says an estimate is impossible since the technology needed is still being developed.

Over the course of three years the total annual budget has exceeded $1 million,” Stacey Johnson, corporate director of conservation and research at San Diego Zoo Global, said.

But the northern white rhino project is fundamentally different from other projects like the Woolly Mammoth Revival, and that makes the money worth it, says Joseph Bennett, an assistant professor at Carleton University, who’s criticized the costs of de-extinction and is not involved in the northern white rhino project.

For starters, unlike the woolly mammoth, the northern white rhino is not extinct — yet.

Only two females remain: Najin and Fatu, who are both related to Sudan and live at the Ol Pejeta Conservancy under armed surveillance.

While the habitat of the woolly mammoth is widely different from what it was thousands of years ago — fragmented by roads and cities, for instance — the habitat of the northern white rhino still exists.

Northern white rhinos have been extinct in the wild since 2008, but only because they were poached for their horns. And that makes humans responsible for their survival.

Rhinos play an important role in the environment, dispersing seeds and keeping vegetation — and as a result, rodents and snakes — under control.

Plus, rhinos are going extinct right now. It’s more like playing Noah than playing God, McCauley says.

There’s one more key difference between northern white rhinos and mammoths: While we only have bits of mammoth DNA, we have plenty of complete genetic material — as well as sperm — from several northern whites.

It’s kept securely frozen in labs all over the world.

Please like, share and tweet this article.

Pass it on: Popular Science